DETECTING KIDNEY DAMAGE
ELEVATED UACR: AN EARLY SIGNAL OF KIDNEY DAMAGE AND CKD PROGRESSION1,2
INFLAMMATION AND FIBROSIS CAN CAUSE ALBUMINURIA, WHICH IS AN EARLY DETECTABLE MARKER OF KIDNEY DAMAGE1-3
UACR testing is used to detect kidney damage by measuring the ratio of albumin to creatinine in the urine1
Rising UACR levels are an indicator of worsening kidney damage and a predictor of more rapid CKD progression1
According to KDIGO, a UACR level above 300 mg/g is very high and warrants particular attention1
Regular UACR testing is encouraged to assess and identify CKD progression early1,4
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CKD: chronic kidney disease; eGFR: estimated glomerular filtration rate; KDIGO: Kidney Disease Improving Global Outcomes; T2D: type 2 diabetes; UACR: urine albumin-to-creatinine ratio.
References:
- Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. Kidney Int Suppl. 2013;3(1):1–150. Return to content
- Campion CG, et al. Can J Kidney Health Dis. 2017;4. doi:10.1177/2054358117705371. Return to content
- Thomas MC, et al. Nat Rev Dis Primers. 2015;1. doi:10.1038/nrdp.2015.18. Return to content
- Cosentino F, et al; ESC Scientific Document Group. Eur Heart J. 2020;41(2):255–323. Return to content
- ACR. National Kidney Foundation. Accessed January 12, 2021. https://www.kidney.org/kidneydisease/siemens_hcp_acr. Return to content